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ORIGINAL ARTICLE
Year : 2013  |  Volume : 12  |  Issue : 2  |  Page : 62-67

Effects of vitamin E administration on phostoxin-induced changes in the kidney of adult Wistar rats


Department of Human Anatomy, Faculty of Medicine, Ahmadu Bello University Zaria, Kaduna State, Nigeria

Correspondence Address:
A O Ibegbu
Department of Human Anatomy, Faculty of Medicine, Ahmadu Bello University Zaria, Kaduna State, 81006
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1596-2393.127963

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Aim: The effect of vitamin E on phostoxin-induced changes in biochemical parameters and the kidney of adult Wistar rats were studied. Materials and Methods: Thirty adult Wistar rats of both sexes were randomly separated into six groups of five rats each. Group 1 was the Control and was given normal saline. Group 2 was exposed to phostoxin for 3 hours per day with vitamin E and Group 3 was exposed to phostoxin for 1΍ hours with vitamin E. Groups 4 and 5 were treated with phostoxin only on exposure time of 1΍ and 3 hours respectively while Group 6 was treated with vitamin E only. The rats were exposed to phostoxin through inhalational method for 7 days and at the end of the exposure period, the rats were sacrificed. The blood and tissues were collected for analysis and were processed for histological studies. Results: The results showed significant changes in body weight of the rats (P < 0.05) while there was a significant increase in weight of the kidneys in Groups 3 and 6 when compared to the Control (P < 0.05). The results of the biochemical parameters Na + , K + , Cl, urea, creatinine and HCO3 showed a significant difference (P < 0.05) between the control and the experimental groups. The results of histological examination of the kidney showed changes in animals exposed to phostoxin when compared to the Control animals. Conclusion: The changes in the kidney depend on the duration of the exposure time while vitamin E administration has been shown to have some level of protection on phostoxin-induced toxicity on the kidney tissues and biochemical parameters of the adult Wistar rats.


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