Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 196
  • Home
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2017  |  Volume : 16  |  Issue : 1  |  Page : 60-70

Microanatomical evaluation of flavonoid-rich fraction of Musa paradisiaca in Aspirin-induced gastric lesion


1 Department of Anatomy, College of Medicine, Ekiti State University, Ado Ekiti, Nigeria
2 Department of Anatomy and Cell Biology, College of Health Sciences, Obafemi Awolowo University, Ile Ife, Nigeria
3 Department of Physiology, College of Medicine, Ekiti State University, Ado Ekiti, Nigeria

Correspondence Address:
Margaret Olutayo Alese
Department of Anatomy, College of Medicine, Ekiti State University, Ado Ekiti
Nigeria
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jeca.jeca_5_17

Rights and Permissions

Aim: This study investigated the healing effects of a flavonoid-rich fraction of Musa paradisiaca (MP) fruit on the histomorphology and histomorphometry of the gastric corpus in Wistar rats following aspirin-induced gastric lesion. This was with a view to providing information on the alternative therapies of treating gastric ulcers using unripe fruits of MP. Materials and Methods: Ninety adult male Wistar rats were randomly assigned into 6 groups of 15 rats each. Aspirin at a dose of 400 mg/kg was dissolved in distilled water and administered as a single oral dose to induce gastric lesions in the test groups of rats. After 24 h, flavonoid fraction of MP was administered to groups C, D, and E at graded doses for 21 days, whereas group F rats received omeprazole at 1.8 mg/kg. On days 14, 21, and 28, five rats from each group were sacrificed. The pH value of the gastric contents was determined, gastric tissues were processed using paraffin wax embedding method; sections were stained with hematoxylin and eosin and Alcian blue/PAS. Data were analyzed using descriptive and inferential statistics. Results: Histomorphological and histomorphometric studies showed a restorative effect of flavonoid fraction of MP in all the treated groups of rats as there was a significant (P = 0.0001) (P = 0.0001) increase in the total mucosal and glandular mucosal layers when compared with the test control. There was a progressive and dose-dependent improvement in staining for mucus-secreting cells in the treated groups as well as a significant (P = 0.0001) increase in a number of cells in the treatment groups when compared with the control. Conclusion: MP attenuated the deleterious effects of aspirin on the stomach by strengthening mucosa defensive factors.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1678    
    Printed67    
    Emailed0    
    PDF Downloaded102    
    Comments [Add]    

Recommend this journal