Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 100
  • Home
  • Print this page
  • Email this page
Year : 2014  |  Volume : 13  |  Issue : 2  |  Page : 45-49

Neurobehavioral and histological effects of Akaki extract on the temporal lobe: Mimicking traditional treatment method

1 Department of Anatomy, Faculty of Basic Medical Science, Ebonyi State University, Abakaliki, Nigeria
2 Department of Anatomy, Federal University, Ndufu-Alike, Ikwo, Ebonyi State, Nigeria
3 Department of Anatomy, University of Nigeria, Enugu Campus, Enugu State, Nigeria

Correspondence Address:
E Finbarrs-Bello
Department of Anatomy, Faculty of Basic Medical Science, Ebonyi State University, Abakaliki, Ebonyi State
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1596-2393.154398

Rights and Permissions

Introduction: Neurobehavioral and histological effect of akaki extract on the temporal lobe of wister rats was carried out. In the study we evaluate a traditional prescription method for the treatment of mental illness using the akaki extract on the temporal lobe. Material and Methods: Twenty rats of average weight 200 g were divided into four groups (n = 5). The rats in the control group (GroupA) were given feed and water, while the rats in the experimental Groups B, C, and D were treated daily with 3 mg/kg, 6 mg/kg and 9 mg/kg of the extract for 7days respectively. Results: Preliminary phytochemical analysis revealed presence of bioactive agents.The behavioral study was performed using the elevated plus-maze (EPM) to access anxiety and routine H and E histological technique. The mean difference was significant at level (P < 0.05). The study showed that the rat exhibited antianxiety property in the EPM. This was more pronounced in the experimental rats. The histological study performed showed that there were progressive changes in the temporal lobe integrity of the sections of the rat in the experimental groups with the rat that received 9 mg/kg of the Akaki extract showing more prominent features of these changes which include cytoplasmic vacuolations and eccentric nuclei within the pyramidal cell layer than granular cell layer as compared to the control group (Group A). Conclusion: In conclusion, the akaki extract shows positive indication of its use in the treatment of mental illness.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded267    
    Comments [Add]    
    Cited by others 1    

Recommend this journal