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Year : 2015  |  Volume : 14  |  Issue : 1  |  Page : 18-23

Effect of curcumin on the expression of Caspase-3 and Bcl-2 in the spleen of diabetic rats

Department of Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Correspondence Address:
Dr. Hagar A Hashish
Department of Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1596-2393.158923

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Background: The spleen is the largest lymphoid organ, concerns with immunological reaction and filtration of blood. Diabetes mellitus is a primary disorder of carbohydrate metabolism that cause depletion of oxidant defense system. Curcumin has anti-inflammatory, anti-proliferative, anti-apoptotic, anti-bacterial, anti-cancer and potent antioxidant activities. Aim of the Work: The purpose of this study was to clarify the effect of induced type I diabetes on the spleen of albino rat and whether these changes could be prevented by curcumin. Materials and Methods: Eighteen albino rats were divided randomly into three groups; control nondiabetic rats; untreated diabetic rats and curcumin-treated diabetic rats. After 8 weeks of treatment, animals were sacrificed; spleen was dissected, processed and stained with hematoxylin and eosin and immunohistochemistry for activated Caspase-3 and Bcl-2 . Results: Diabetes caused decrease in the body weight, degeneration of splenocytes, increased Caspase-3, and reduced Bcl-2 activity. Treatment with curcumin decreased the blood glucose level, prevented the loss of body weight and protected the spleen against diabetic induced structural changes. Conclusion: The current results suggested that consumption of curcumin protected the spleen against diabetic induced changes, reduced Caspase-3, and improved Bcl-2 expression. Thus, curcumin may attenuate the pathologic effects observed in the spleen of diabetic rats.

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