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Year : 2017  |  Volume : 16  |  Issue : 1  |  Page : 41-45

Effects of rauvolfia vomitoria on the cerebellar histology, body and brain weights of albino wistar rats

1 Department of Anatomy, University of Uyo, Uyo, Nigeria
2 Department of Anatomy, University of Calabar, Calabar, Nigeria
3 Department of Biochemistry, University of Uyo, Uyo, Nigeria

Correspondence Address:
Aquaisua Nyong Aquaisua
Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Uyo, Uyo
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jeca.jeca_35_16

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Background: Rauvolfia vomitoria is a medicinal plant used in the treatment of hypertension and mental disorders. The effects of the ethanolic root bark extract of R. vomitoria were determined in this study. Materials and Methods: Eighteen male and female young albino Wistar rats weighing 100–160 g were randomly assigned to three Groups 1, 2, and 3 of 6 rats each. The control (Group 1) received 0.1 ml of 20% solution of Tween 80, while Groups 2 and 3 received 200 mg/kg and 300 mg/kg of the root bark extract of R. vomitoria, respectively, for 14 days. The rats were sacrificed on the 15th day; the cerebellum of each rat was harvested, processed, and then stained using the hematoxylin and eosin method and immunohistochemical staining technique for glial fibrillary acidic protein (GFAP). Results: The results showed swelling and atrophy of Purkinje cells, proliferation of reactive astrocytes and increased expression of GFAP, a significant reduction in the body weight of experimental animals, but no difference in brain weight compared with the control. Conclusion: The ethanolic root bark extract of R. vomitoria has a deleterious effect on the cerebellum and body weight of young albino Wistar rats but does not affect brain weight.

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