Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 107
  • Home
  • Print this page
  • Email this page
Year : 2017  |  Volume : 16  |  Issue : 1  |  Page : 71-76

Evaluation of the comparative effects of antihypertensive drugs: Methyldopa and Moringa oleifera leaves on the hypothalamic–pituitary–gonadal axis in male Wistar rat

1 Department of Anatomy, College of Health Sciences, Osun State University, Osogbo, Nigeria
2 Department of Biochemisty, College of Health Sciences, Osun State University, Osogbo, Nigeria

Correspondence Address:
Opeyemi Samson Adeleke
Department of Anatomy, College of Health Sciences, Osun State University, Osogbo
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jeca.jeca_6_17

Rights and Permissions

Background: Antihypertensive drugs have been reported to induce reproductive toxicity, and hypothalamic–pituitary–gonadal axis (HPG) is responsible for the control of reproductive functions. Hence, there is a need to compare the effects of taken commonly used synthetic and natural antihypertensive drugs (Methyldopa and Moringa oleifera) on HPG-axis. Aim: This study was aimed to determine the hypothalamic–pituitary–gonadal responses to the administration of methyldopa and aqueous extract of Moringa oleifera leaves in male Wistar rats. Methodology: Twenty-five male adult Wistar rats weighed between 150 and 200 g were divided into five groups (A–E), with each group comprising fi ve rats. Group E was designated as the control group which received physiological saline while rats of Group A and B received 200 and 400 mg/kg body weight of M. oleifera, respectively. Rats of Group C and D received 500 and 1000 mg/kg body weight of methyldopa, respectively, for 30 days. Results: Andrological parameters (sperm count, sperm morphology, sperm motility, serum testosterone, follicle-stimulating hormone, and luteinizing hormone concentration) in Group B rats showed significant increase when compare with the methyldopa-treated group (C and D) and control group E rats. Group D rats showed slight abnormalities in sperm morphology and slight decrease in sperm motility when compare with the control group E. Histoarchitecture of the testes of Group A, B, and E rats showed normal seminiferous tubules with full maturation of the germinal cell layers and only Group B rats contained more spermatozoa in their lumen. Group C and D rats showed some of their seminiferous tubules with incomplete maturation of germinal cell layers with their lumens contained fat deposit with no spermatozoa. Conclusion: The aqueous extract of M. oleifera leaves as an antihypertensive drug showed high beneficiary effects on male fertility over methyldopa.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded216    
    Comments [Add]    

Recommend this journal