Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 95
  • Home
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2018  |  Volume : 17  |  Issue : 1  |  Page : 8-12

Morphological effects of chronic administration of zidovudine on the intracranial auditory relay centers of adult Wistar rats


1 Department of Human Anatomy and Cell Biology, Faculty of Basic Medical Sciences, Delta State University, Abraka, Delta State, Nigeria
2 Department of Basic Medical Sciences, Achievers University, Owo, Ondo State, Nigeria
3 Department of Anatomy, University of Medical Sciences, Ondo City, Nigeria
4 Department of Anatomy, Federal University of Technology, Akure, Ondo State, Nigeria

Correspondence Address:
Dr. Kingsley Afoke Iteire
Department of Anatomy, University of Medical Sciences, Ondo City
Nigeria
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jeca.jeca_34_17

Rights and Permissions

BACKGROUND: Zidovudine is one of the very active antiretroviral treatments which have been effective in several combination regimens for the treatment of HIV disease. Widely accepted theories have recognized that such treatment regimens agents are capable of penetrating the blood brain barrier and may continue to exert damage to the brain, after antiviral treatment. AIMS AND OBJECTIVES: The objective of this study is to investigate zidovudine-induced morphological changes in auditory relay centres of the brain. It is likely that the adverse effects of zidovudine as reported by several researches may be due to some underlying effect on the microanatomy of the intracranial auditory relay centres. MATERIALS AND METHODS: Forty rats with an average weight of 200g were randomly assigned into treatment (n1=20) and control (n2=20) groups. Zidovudine was dissolved in distilled water and a dose of 300mg/70kg (0.857mg/200g) was calculated and administered twice daily to the rats of the treatment group orally by the use of an orogastric tube for thirty days. The control group received equal volume of distilled water as placebo. The rats were later sacrificed by cervical dislocation and the inferior colliculi and medial geniculate bodies were dissected for morphometric and histological analysis. RESULTS/DISCUSSION: Results from this study revealed a significant increase (p < 0.05) in weight of the inferior colliculus of the treated rats but a significant decrease (p < 0.05) in weight of the medial geniculate body of the treated rats, as compared to their corresponding control groups. Histologically, the treated tissues revealed similar necrotic and cellular degenerative changes in the stroma when compared to tissues from the control group. These observations confirm the adverse effects of Zidovudine on the inferior colliculus and medial geniculate body of adult Wistar rats. However, it was also observed in this study that the effect of zidovudine was not similar on the two intracranial relay centres as previously believed. CONCLUSION: Further studies are needed in corroborating these observations, especially to determine the mechanism of hearing loss that is associated with zidovudine therapy..


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed979    
    Printed70    
    Emailed0    
    PDF Downloaded97    
    Comments [Add]    

Recommend this journal